Polymorphisms of ATG5 Gene Are Associated with Autoimmune Thyroid Diseases, Especially Thyroid Eye Disease

Table 5

Allele frequencies of rs6568431, rs548234, and rs6937876 in ophthalmopathy and nonophthalmopathy GD patients.

SNP	Alleles	Ophthalmopathy (%)	Nonophthalmopathy (%)	value	OR	95% CI
rs6568431	A	61 (32.80)	314 (34.13)	0.762	0.942	(0.674-1.317)
	C	125 (67.20)	606 (65.87)
	AA	8 (8.60)	51 (11.09)	0.479	0.755	(0.346-1.648)
	AC+CC	85 (91.40)	409 (88.91)
rs548234	C	48 (25.81)	259 (28.15)	0.515	0.888	(0.620-1.270)
	T	138 (74.19)	661 (71.85)
	CC	3 (3.23)	40 (8.69)	0.072	0.350	(0.106-1.156)
	CT+TT	90 (96.77)	420 (91.31)
rs6937876	G	59 (31.72)	315 (34.24)	5.42E-18	0.242	(0.173-0.339)
	A	127 (68.28)	605 (65.76)
	GG	7 (7.53)	54 (10.66)	0.237	0.612	(0.269-1.391)
	AG+AA	86 (92.47)	406 (88.26)