Research Article

Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p

Figure 5

Summary of findings. RSV and pNS1 promote the expression of miR-19a-3p in A549 cells. NS1 small interfering RNA alleviates the effect. pNS1 increases the levels of 5-lipoxygenase, interleukin-5, and leukotriene B4, which could be attenuated by inhibitors of miR-19a-3p or 5-lipoxygenase. Black arrows: activation; dotted red lines: inhibition. RSV: respiratory syncytial virus; NS1: nonstructural protein 1; pNS1: NS1 expression plasmid; siNS1: NS1 small interfering RNA.