Research Article

Clinical Significance of OX40 and OX40 Ligand in the Peripheral Blood of Patients with Myasthenia Gravis

Table 1

The clinical characteristics of the study population.

Clinical featuresMembrane-bound moleculesSoluble molecules
Baseline ()Remission ()Relapse ()HC () valueBaseline ()Remission ()Relapse ()HC () value

Age (years)49.0 (37.0, 63.0)46.0 (36.0, 58.0)48.0 (32.0, 58.0)47.0 (32.5, 58.5)0.75443.0 (33.0, 66.0)39.0 (34.0, 57.0)50.5 (40.0, 62.0)44.5 (34.0, 54.0)0.258
Age of onset, (%)
 EOMG ()13 (33.3)17 (40.4)12 (54.6)n.a.0.26916 (43.2)19 (63.3)16 (47.1)n.a.0.233
 LOMG ()9 (23.1)18 (42.9)8 (36.4)n.a.0.16516 (43.2)11 (36.7)18 (52.9)n.a.0.417
Sex, (%)0.5570.141
 Female20 (51.3)27 (64.3)14 (63.6)19 (52.8)19 (51.3)21 (70.0)20 (58.8)23 (76.7)
 Male19 (49.7)15 (35.7)8 (36.4)17 (47.2)18 (48.7)9 (30.0)14 (41.2)7 (23.3)
MGFA classification, (%)0.001≤0.001
 OMG25 (64.1)30 (71.4)3 (13.6)n.a.22 (59.5)19 (63.3)3 (8.8)n.a.
 GMG14 (35.9)12 (28.6)19 (86.4)n.a.15 (40.5)11 (36.7)31 (91.2)n.a.
Thymoma, (%)0.0610.005
 Without32 (82.1)35 (83.3)13 (59.1)n.a.27 (73.0)21 (70.0)13 (38.2)n.a.
 With7 (17.9)7 (16.7)9 (40.9)n.a.10 (27.0)9 (30.0)21 (61.8)n.a.
AchR-Ab, (%)0.0031.000
 Positive, (%)22 (56.4)35 (83.3)20 (90.9)n.a.32 (86.5)30 (100.0)34 (100.0)n.a.
 Negative, (%)19 (43.6)7 (16.7)2 (9.1)n.a.5 (13.5)0 (0.0)0 (0.0)n.a.
Disease duration (months)3 (1.0, 24.0)22.5 (8.0, 46.0)22 (7.0, 40.0)n.a.≤0.0011 (1.0, 2.0)15 (10.0, 38.0)20 (3.0, 52.0)n.a.≤0.001
QMGs7.0 (5.0, 10.5)7.0 (4.0, 8.0)13.0 (11.0, 18.0)n.a.≤0.0018.0 (6.0, 12.0)7.0 (6.0, 9.0)14.0 (12.0, 20.0)n.a.≤0.001

Abbreviations: HC: healthy control; EOMG: early-onset myasthenia gravis; LOMG: late-onset myasthenia gravis; MGFA: Myasthenia Gravis Foundation of America; AchR-Ab: acetylcholine receptor antibodies; QMGs: quantitative myasthenia gravis scores.