Anticancer Effect of Puerarin on Ovarian Cancer Progression Contributes to the Tumor Suppressor Gene Expression and Gut Microbiota Modulation

Figure 1

Puerarin inhibits OC cell proliferation and induces cell apoptosis. (a) OC cell lines NuTu-19 and SKOV3 were coincubated with increasing concentrations of puerarin (0-320 μg/mL) for 24 h and 48 h, and CCK-8 assay was performed to detect the cell viability. (b) NuTu-19 and SKOV3 cells were coincubated with 0, 40, 80, and 160 μg/mL of puerarin, and cell proliferation was detected using EdU staining. (c) Cell apoptosis rates of NuTu-19 and SKOV3 cells were assessed by Annexin V-FITC/PI staining with flow cytometry. The data are presented as , . , , compared to the 0 μg/mL puerarin group. OC: ovarian cancer.

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