Anticancer Effect of Puerarin on Ovarian Cancer Progression Contributes to the Tumor Suppressor Gene Expression and Gut Microbiota Modulation

Figure 6

Puerarin modulates the diversity of the gut microbiota in OC rats. Rat feces were collected for 16S rDNA sequencing to analyze the effect of puerarin on the gut microbiota in OC model rats. (a) Venn diagram shows the features of the analyzed feces samples from all groups. (b) Stacked bar chart of the species richness analysis from the family, genus, to species of the detected microbes in the four groups. (c) Alpha diversity analysis, including the Shannon, Simpson, and Chao1 indexes, was used to assess the diversity of the intestinal microbes in the four groups. (d) Beta diversity of the intestinal microbiota was evaluated using principal coordinate analysis (PCoA) and Unweighted Pair Group Method with Arithmetic mean (UPGMA) clustering analysis. OC: ovarian cancer.

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