Anticancer Effect of Puerarin on Ovarian Cancer Progression Contributes to the Tumor Suppressor Gene Expression and Gut Microbiota Modulation

Figure 7

The inhibitory effect of puerarin on OC was associated with differences in the gut microbiota communities among the OC model rats. (a) Linear discriminant analysis Effect Size (LEfSe) analysis was performed to identify the key gut microbes. There were 49 markedly changed gut microbes with linear discriminant analysis (LDA) and among the four groups. (b) Cladogram of the identified gut microbes. (c) Expression of the significant gut microbes at the genus level in the four tested groups. (d) Correlation heatmap of the gut microbiota. (e) Metabolic pathway analysis of the gut microbes. OC: ovarian cancer.

(a)

(b)

(c)

(d)

(e)