Identification of Important Modules and Hub Gene in Chronic Kidney Disease Based on WGCNA

Figure 5

The hub genes screened out were validated in the validation dataset including GSE142153 and GSE70528. (a) A total of 6 molecules were considered to be highly associated with CKD, including CEBPZ, IFI16, LYAR, BRIX1, BMS1, and DDX18. Details of these hub genes include degree, MCODE_score in Cytoscape, fold changes, and value in the interaction network in CKD patients compared to healthy controls. (b) mRNA expression of CEBPZ. (c) mRNA expression of IFI16. (d) mRNA expression of LYAR. (e) mRNA expression of BRIX1. (f) mRNA expression of BMS1. (g) mRNA expression of DDX18. CKD: patients with chronic kidney disease; HC: healthy human control.

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