HMGA1 Promotes Macrophage Recruitment via Activation of NF-κB-CCL2 Signaling in Hepatocellular Carcinoma

Figure 1

HMGA1 expression is associated with macrophage infiltration in HCC. (a) Venn diagram showed the macrophage-associated genes, differentially expressed genes (DEGs), and prognosis-associated genes in HCC. (b) The Kaplan-Meier curve showed the prognostic value of HMGA1 in HCC; data were obtained from the TCGA cohort and the median value of HMGA1 was set as a cutoff; high group () and low group (). (c) The pan-cancer expression pattern of HMGA1 in tumor tissue and corresponding nontumor tissues was acquired from the TIMER database (https://cistrome.shinyapps.io/timer/). ACC = adrenocortical carcinoma; BLCA = bladder urothelial carcinoma; BRCA = breast invasive carcinoma; CESC = cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL = cholangiocarcinoma; COAD = colon adenocarcinoma; DLBC = lymphoid neoplasm diffuse large B-cell lymphoma; ESCA = esophageal carcinoma; GBM = glioblastoma multiforme; HNSC = head and neck squamous cell carcinoma; KICH = kidney chromophobe; KIRC = kidney renal clear cell carcinoma; KIRP = kidney renal papillary cell carcinoma; LAML = acute myeloid leukemia; LGG = brain lower grade glioma; LIHC = liver hepatocellular carcinoma; LUAD = lung adenocarcinoma; LUSC = lung squamous cell carcinoma; MESO = mesothelioma; OV = ovarian serous cystadenocarcinoma; PAAD = pancreatic adenocarcinoma; PCPG = pheochromocytoma and paraganglioma; PRAD = prostate adenocarcinoma; READ = rectum adenocarcinoma; SARC = sarcoma; SKCM = skin cutaneous melanoma; STAD = stomach adenocarcinoma; TGCT = testicular germ cell tumors; THCA = thyroid carcinoma; THYM = thymoma; UCEC = uterine corpus endometrial carcinoma; UCS = uterine carcinosarcoma; UVM = uveal melanoma. (d) The association between HMGA1 expression and immune components (B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil, and dendritic cell) in HCC.

(a)

(b)

(c)

(d)