HMGA1 Promotes Macrophage Recruitment via Activation of NF-κB-CCL2 Signaling in Hepatocellular Carcinoma

Figure 5

Mechanism model for HMGA1-mediated CCL2 expression in HCC. HMGA1 is located in the nucleus and functions together with NF-κB to induce CCL2 expression. Furthermore, CCL2 recruits macrophages to the tumor microenvironment and leads to tumor progression.