Antibody Avidity and Neutralizing Response against SARS-CoV-2 Omicron Variant after Infection or Vaccination

Figure 2

RBD binding IgG antibody avidity and neutralizing antibody titers to SARS-CoV-2 in SARS-CoV-2 infected patients and vaccinated cohorts: (a) RBD binding IgG antibody titers against wt virus; (b) RBD binding IgG antibody avidity against wt virus; (c) neutralizing antibody titers against wt virus; (d) RBD binding IgG antibody titers against Omicron variant; (e) anti-RBD IgG antibody avidity against Omicron variant; and (f) neutralizing antibody titers against Omicron variant. The antibody avidity was expressed as avidity index (AI). Tukey boxplots show outlier values (dots), medians (middle line), and third and first quartiles (boxes), while the whiskers display the minimum and maximum values. Horizontal dashed line represents the lower limit of quantification (LLOQ) of microneutralization (MN) assay and AI range (low, intermediate, and high). Statistically significant differences were analyzed by Kruskal-Wallis and Dunn’s multiple comparisons test ().

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