The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation
Table 1
Demographic and clinical characteristics of the study population.
CAMR group ()
IgAN group ()
Stable group ()
value
Age (years)
0.267
BMI (kg/m2)
0.533
Male
11 (73.3%)
4 (36.3%)
8 (80.0%)
0.070
Female
4 (26.7%)
7 (63.63%)
2 (20.0%)
Posttransplantation time (years)
6 (3, 9)
6 (3, 9)
6.5 (3.75, 8.25)
0.912
PRA (%)
3.19 (0.00, 3.55)
0.40 (0.00, 0.00)
2.02 (0.00, 3.95)
0.295
Induction therapy
0.823
Anti-CD25 mAb
3
1
1
Basiliximab
1
3
2
Antithymocyte globulin
4
2
2
Total HLA mismatches
4 (4, 5)
4 (3, 4)
4 (4, 6)
0.055
Anti-HLA class I positive
2 ()
0 ()
2 ()
0.418
Anti-HLA class II positive
7
1
1
0.054
DSA positive
7
1
0
0.073
eGFR (ml/min/1.73 m2)
50.91 (21.19, 58.68)a
57.02 (40.79, 68.51)
69.40 (67.42, 74.03)
0.003
Scr (μmol/l)
138.0 (110.0, 292.0)a
122 (101, 127)
106.5 (93.5, 113.0)
0.008
Cys-c (mg/l)
1.66 (1.40, 3.25)a
1.32 (1.21, 1.67)
1.27 (1.17, 1.35)
0.003
Data are shown as mean (SD) or median (interquartile range). Abbreviations: BMI: body mass index; Scr: serum creatinine; PRA: panel reactive antibodies, anti-CD25 mAb, and anti-CD25 monoclonal antibody; HLA: histocompatibility antigen; DSA: donor-specific antibody; eGFR: estimated glomerular filtration rate; Cys-c: cystatin C. , indicated by an asterisk ()., CAMR group vs. stable group.
