Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer

Figure 1

Identification of endothelial cells in TNBC biopsies. (a) Flow cytometry analysis revealed three endothelial cell subclusters in TNBC biopsied tissues, featured by the expression of ATP1B3, HSPA1B, and KRT7, respectively. Data represent similar results acquired from five independent experiments. (b) UMAP plots showed 9 cell types in the normal human breast and 10 cell types in TNBC biopsy tissues. The boxed cell types indicate endothelial cells. (c) Violin plots exhibited the expression pattern of endothelial cell markers (CD93, CDH5, and PECAM1) and a leukocyte marker (PTPRC). (d) Flow cytometry analysis identified the expression of CDH5 and CD93 from endothelial cells in TNBC biopsies. Data represent similar results acquired from three independent experiments.

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