A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641

Figure 4

NK-1R positively regulated the proliferation, migration, and invasion of pancreatic cancer cells. (a, b) The levels of NK-1R gene and protein expression in the Ctrl, NC + SP, NK-1R + SP, and siNK-1R + SP groups. (c, d) The levels of NF-κB p65, AKT, and p-AKT protein expression were assessed in different groups. (e, f) Cell proliferation rates in the Ctrl, NC + SP, NK-1R + SP, and siNK-1R + SP groups were analyzed by CCK-8 and EdU staining assays. (g, h) Transwell and wound-healing assays were performed to evaluate cell migration ability. (i) Cell invasion was assessed by the Transwell assay. , vs. Ctrl. ^#, ^### vs. NC + SP group.

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