Identification of Metabolite Markers Associated with Kidney Function
Table 1
Demographic and clinical characteristics of the study population.
Variable
mL/min per 1.73 m2
mL/min per 1.73 m2
mL/min per 1.73 m2
mL/min per 1.73 m2
Overall
Sample size,
5
15
11
22
53
Age (y)
37.2 (13.7)
42.8 (14.6)
49.0 (13.7)
56.4 (11.8)
49.2 (13.6)
0.112
Female (%)
4 (80.0)
6 (40.0)
2 (18.2)
7 (31.8)
19 (35.8)
0.693
Body mass index (kg/m2)
22.0 (1.1)
22.7 (2.3)
24.0 (2.1)
23.3 (2.8)
23.2 (2.5)
0.283
Diabetes prevalence (%)
2 (40.0)
6 (40.0)
6 (54.5)
9 (40.9))
23 (22.1)
0.999
Hypertension prevalence (%)
2 (60.0)
9 (60.0)
8 (72.7)
14 (63.6)
33 (62.2)
0.991
Hyperuricemia prevalence (%)
2 (40.0)
2 (13.3)
2 (18.2)
5 (22.7)
11 (20.7)
0.987
Uric acid-lowing medication use (%)
2 (40.0)
2 (13.3)
2 (18.2)
5 (22.7)
11 (20.7)
0.987
Antihypertensive medication use (%)
2 (60.0)
9 (60.0)
8 (72.7)
14 (63.6)
33 (62.2)
0.991
Glucose-lowering drug use (%)
2 (40.0)
6 (40.0)
6 (54.5)
9 (40.9))
23 (22.1)
0.999
Lipid-lowering medication use (%)
1 (20.0)
4 (26.7)
7 (63.6)
10 (45.4)
22 (41.5)
0.816
Systolic BP (mmHg)
133.6 (19.4)
138.9 (17.8)
149.1 (16.3)
142.2 (24.1)
141.9 (20.5)
0.348
Diastolic BP (mmHg)
86.9 (11.4)
85.9 (13.1)
88.9 (11.4)
85.6 (11.6)
86.9 (11.4)
0.735
Creatinine
0.6 (0.1)
1.4 (1.7)
1.8 (0.7)
5.8 (2.6)
3.2 (2.9)
<0.001
Cystatin C
0.8 (0.1)
1.3 (0.9)
1.9 (0.6)
3.9 (0.9)
2.5 (1.5)
<0.001
eGFRcr-cys (mL/min per 1.73 m2)
115.4 (14.9)
89.1 (26.4)
49.2 (23.4)
12.4 (7.9)
51.5 (42.2)
<0.001
mGFRcr-cys (mL/min per 1.73 m2)
98.3 (7.5)
73.8 (9.6)
43.5 (8.8)
14.2 (6.3)
45.1 (31.2)
Continuous measures are summarized as the (SD), and categorical variables are given as percentages. Values for categorical variables are given as numbers (percentages). Abbreviations: BP: blood pressure; eGFRcr-cys: estimated glomerular filtration rate, calculated by Chronic Kidney Disease Epidemiology Collaboration; mGFR: measured glomerular filtration rate. Hypertension was defined as systolic mmHg or 140 or diastolic mmHg or receiving antihypertensive medications. Diabetes was defined as fasting blood mg/dL or receiving antidiabetic medications. Hyperuricemia was defined as uric acid mg/dL (female) and ≧ 7.0 mg/dL (male) or receiving uric acid-lowering medication.
