Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway

Figure 1

rhALR attenuates renal damage after I/R injury induction. (a, b) After 60 min of bilateral renal ischemia, blood samples were collected at 24, 48, and 72 h, followed by renal reperfusion, and serum creatinine and blood urea nitrogen were measured. The increase of two indexes in the rhALR1 and rhALR2 groups was withdrawn (). Urea nitrogen and serum creatinine in the I/R+rhALR2 group were lower than those in the I/R+rhALR1 group (). (c) HE staining of 24 h renal slices in the I/R group showed severe renal tubule necrosis. Renal morphology was preserved after rhALR1 and rhALR2 treatment (magnification, ×200). Histological changes were assessed semiquantitatively for tubular necrosis. The tubular damage score was given by two uninformed observers. Data were expressed as the . as compared to the sham group, and ^# as compared to the I/R+saline group.

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