Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway

<div>rhALR alleviates inflammation in H/R-induced HK2 cells. (a, b) Real-time PCR and ELISA analysis showed that the mRNA and protein expressions of IL-1<i>β</i>, IL-6, and TNF-<i>α</i> were upregulated after H/R induced reoxygenation for 12 h in HK2 cells. No above changes were observed in the H/R+rhALR group and the negative control group. And exogenous anti-rhALR Ab evidently blocked the anti-inflammatory effect of rhALR. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway 