Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway

<div>rhALR downregulated the expression of TLR4 and endogenous ligands after I/R injury. (a, b) TLR4 mRNA expression after renal I/R injury was measured by immunohistochemical (magnification, ×200) and real-time PCR methods, respectively. TLR4 expression was increased markedly in kidneys after rat I/R injury. Intraperitoneal injection of rhALR markedly decreased the expression of TLR4 vs. I/R+saline. TLR4 protein expression in untreated control cells was low. (c) The endogenous ligand mRNA expression began to increase since 24 h and reached the peak at 72 h following I/R injury. Expression of these mRNA downregulation in I/R+rhALR1 and I/R+rhALR2 at the same points. 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Journal of Immunology Research

fig6

Figure 6

Figure 6: Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway 