Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy

Figure 5

Selection and validation of the diagnostic gene. (a) Horizontal bar chart shows genes ranked by SVM-RFE. Red bars and blue bars represent the top-ranked 5 genes in comparison to AR and STA samples, respectively. (b and c) Violin plots show differences in expression levels of RBBP7 among three types of allografts in the training and validation cohorts. (d and e) ROC curves show the diagnostic ability of RBBP7 between BKVN and rejection samples in the training and validation cohorts. (f and g) ROC curves show the diagnostic ability of RBBP7 between BKVN and STA samples in the training and validation cohorts. (h) Radar chart shows the AUC of RBBP7 and other previously reported genes for BKVN diagnosis in training and validation cohorts. (i and j) GSEA reflects pathways enriched in BKVN samples with higher expression levels of RBBP7 in training and validation cohorts. TCMR: T cell-mediated rejection. ROC: receiver-operating characteristic. AUC: area under the curve. ; ; , ns: not statistically significant.

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