Dysregulation of NK and CD8⁺T Cells by the Microbiota Promotes the Progression of Lung Cancer

Figure 1

Progression of lung cancer was significantly inhibited in Abt-Kras mice. (a) Kras-mutated mice and paired control wild-type (WT) mice were infected intranasally (i.n.) with Lenti-Cre after being treated with combined antibiotics (Abt) in their drinking water for 5 weeks. The mice continued to receive Abt water throughout the experiments and tissues were harvested at 5 (stage 1), 10 (stage 2), and 15 (stage 3) weeks, respectively, after activation of the KRAS gene. Another two groups of Kras-mutated mice and WT mice were fed normal drinking water as controls. (b) Representative histology of the H&E-stained lungs of Kras mice and WT mice that receive Abt or normal drinking water at different stages of lung cancer. The number of tumour nodules in the two groups of Kras mice indicated in (b) is shown in (c). Each symbol in (c) represents an individual mouse; . Data are presented as . and .

(a)

(b)

(c)