The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis

Figure 4

Autoimmune cholangitis in IL-21^-/-p40^-/-IL-2Ra^-/- mice. (a) Serum AMA levels in IL-21^-/-p40^-/-IL-2Ra^-/- () and p40^-/-IL-2Ra^-/- () mice. (b) Representative H&E of the liver at 100x and 400x magnification. (c) Liver pathological score of IL-21^-/-p40^-/-IL-2Ra^-/- () and p40^-/-IL-2Ra^-/- () mice. (d) Densities of liver MNCs in IL-21^-/-p40^-/-IL-2Ra^-/- () and p40^-/-IL-2Ra^-/- () mice. (e) Numbers of T cells in the liver from IL-21^-/-p40^-/-IL-2Ra^-/- () and p40^-/-IL-2Ra^-/- () mice. (f) Percentages and numbers of CD4⁺ T cells in the liver from IL-21^-/-p40^-/-IL-2Ra^-/- () and p40^-/-IL-2Ra^-/- () mice. (g) Representative flow cytometry plots and percentages of GC B cells in lymph nodes from IL-21^-/-p40^-/-IL-2Ra^-/- () and p40^-/-IL-2Ra^-/- () mice. .

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