Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen

Figure 4

Proliferation of T cell subpopulations in IEL cells promoted by the S2-Ag85A vaccine. (a) CD4+ and CD8+ cell subpopulation screening: CD3 + CD8 + αβ and CD3 + CD8 + αα cell proliferation was significantly increased (). (b) +T cell subpopulation screening. (c) Flow assay CD8α + IEL subpopulation results; green, negative unstained; blue, normal control group; red, S2-Ag85A group. (d) Flow detection of CD8β + IEL subpopulation results; green, negative unstained; blue, normal control group; red, S2-Ag85A group. (e) Flow cytometric detection of TCR + T subpopulation results; green, negative unstained; blue, normal control group; red, S2-Ag85A group.

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