Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype

Table 2

Information on the 9 hub genes.

Gene symbol	Abbreviations	Function
Ribonucleotide reductase M2B	RRM2B	p53R2 is a subunit of the ribonucleotide reductase complex [26].
Cancer susceptibility candidate 3	CASC3	As a core component of the exon junction complex (EJC), CASC3 was described to be pivotal for EJC-dependent nuclear and cytoplasmic processes [27].
Splicing factor 3A subunit 1	SF3A1	SF3A1 is a protein coding gene [28].
Importin-5	IPO5	A member of the karyopherin beta subunit locates in the 13q32 chromosomal region and has been demonstrated to play a vital role in the translocation of various proteins [29].
Bardet-Biedl syndrome 10	BBS10	Among its related pathways are cargo trafficking to the periciliary membrane and organelle biogenesis and maintenance [30].
Alpha thalassemia/mental retardation, X-linked	ATRX	ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3 [31].
Werner’s syndrome gene	WRN	A member of the RECQ family of DNA helicases plays essential roles at stalled forks to counteract replication stress, thereby ensuring genomic stability [32–34].
Poly(ADP-ribose) polymerase 1	PARP1	Upon activation, PARP1 attaches ADP-ribose polymer chains to target proteins using nicotinamideadenine dinucleotide (NAD+) as a substrate and facilitates the process of DNA repair [35].
Ran-binding protein 6	RANBP6	As member of the importin β superfamily and EGFR regulator [36].