Research Article

Saikosaponin-d Attenuates Hashimoto’s Thyroiditis by Regulating Macrophage Polarization

Table 2

Related gene targets of HT and SSd.

Drug/diseaseTargetsNumber

SSdGSTP1, MAPK14, KDR, CA2, SPSB1, MTOR, SLC5A1, MAPK8, ICAM2, HSD17B1, BMP2, EGFR, FGF21, FTO, AMY1A, SPSB2, ACE2, PDE4B, MAPK10, ADORA1, SULT2A1, LGALS7, TNNC1, MAPK3, CYP3A7, DHODH, CA12, ITGAL, AMY1B, BCHE, AMY1C, MMP13, PGR, ANG, HCK, METAP1, KIF11, PIM1, CASP7, TSC22D3, NR1H2, HSD11B1, BACE1, CDK2, NUDT9, MAPK1, CTSD, SEC14L2, LTB4R, ADAM8, EPHB4, MAP2K4, SPSB4, SOCS3, TTR, CHEK1, QPCT, AURKA, CYP1A2, PTAFR, PPIA, FAP, ALB, F3, RB1, CFB, CBL, MAPKAPK2, TREM1, PTPRA, HDAC8, FGF2, RAB5A, AKR1C2, GCK, SMAD7, FCAR, STS, CDKN1A, IMPA1, ABCC1, PTPN2, MAOB, CLPP, TGFBR2, PAH, MTAP, CLC, OPRK1, DDX6, CASP3, METAP2, CALM2, NABP2, FKBP1A, BDNF, DCX, MMP3, APOA2, PDGFRB, HSD17B11, HTR2C, RORA, CA1, FOXG1, CTSV, SLC5A2, FGF1, PNP, F2, NABP1, CYP3A4, RBL2, TFEB114

SSd-HTPTPN22, GC, FASN, GBA, IL6, FAS, TP53, TNFRSF11B, STAT3, VEGFA, FASLG, IL1012

HTTNFSF12, IL12B, TNFSF8, CALCA, CGA, TGFB1, CXCL10, FOXP3, IL23A, IFNL3, CLDN1, TNFSF18, DIO1, MX1, TNFRSF8, CASP8, EDN1, IL18R1, MAGI2, CD40, RET, AMH, RHO, IL4, IL18RAP, LEP, IL1R1, TNFSF4, AATF, SLC26A4, IL37, IL1RL1, CD80, CD1C, ABCC11, IL17A, TBX21, MBL2, S100A9, DPP4, CALCA, NRAS, PTPRC, COL1A1, HGF, FCGRT, TSHR, PTGDR2, TG, TPO, SH2B3, TNFSF13B, PER3, CCL5, SPP1, SELENOS, KRT19, PDE8B, BRAF, DIO2, TLR2, SMARCA2, IL18, IFNL1, EDNRA, TSHB, FCGR2B, ABCC6, VDR, NAAA, IL33, AGER, IFNG, TNFRSF13C, SLTM, CD1A,TNFAIP3, HLA-A, TNFRSF1A, CXCL9, NFE2L2, ARID5B, IFIH1, HLA-DRB4, IL23R, IL1B, TLR4, SGPP1, SLC30A8, CTLA4, GGCX, CYP27B1, MET, TNF, IL22, NCAM1, IL6R97