C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection

Figure 10

The impact of C/EBPα in AD rats in vivo. C/EBPα expression in vivo was knocked down using C/EBPα shRNA lentivirus in AD rats, and knockdown was confirmed at both mRNA level by RT-qPCR (a) and protein level by Western blot (b) ( vs. model). The representative images (c) and expression levels (d) of α-SMA and OPN in the aortic vessels were determined by the immunohistochemistry ( vs. control, ^# vs. model).

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