Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome

Figure 4

DAPT treatment delayed aortic expansion and improved survival of Fbn1^mgR/mgR (mgR) mice. (a) Timeline of mouse experiments: WT and mgR mice were treated with DAPT (10 mg/kg) or DMSO by subcutaneous injection started at PD10 (start) and stopped at PD42 (stop). (b) Aortic diameters of mgR mice and WT littermates receiving DAPT or DMSO (/group) were measured by ultrasound (US) at 5, 8, and 12 weeks of age. The aortic diameters of DMSO-treated mgR mice were larger compared with WT controls at all time points (^† compared to WT controls). DAPT treatment inhibited aortic dilation of mgR mice at the 5-week time point ( compared to DMSO-treated mgR mice). (c) Representative ultrasound images of ascending aorta of mice at 5-week time point. (d) Life table analysis of WT (/group) and mgR (/group) mice treated with DAPT or DMSO from PD10 to PD42. Survival rate of mgR mice treated with DAPT was improved compared with DMSO-treated mgR mice ().

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