Methotrexate Treatment Suppresses Monocytes in Nonresponders to Pneumococcal Conjugate Vaccine in Rheumatoid Arthritis Patients

Figure 2

Percentage of basophils (of leukocytes) in peripheral blood from (a) patients with rheumatoid arthritis before methotrexate treatment and after 6-12 weeks on methotrexate, (b) healthy controls (HC), patients without disease-modifying antirheumatic drug treatment (0DMARD group), and patients on MTX treatment (MTX), before administration of 13-valent pneumococcal conjugate vaccine. Wilcoxon matched-pairs signed rank test and Mann–Whitney test were used to calculate level of significance. Data are presented with medians.

(a)

(b)