Effect of Perioperative Interleukin-6 and Tumor Necrosis Factor-α on Long-Term Outcomes in Locally Advanced Gastric Cancer: Results from the CLASS-01 Trial

Table 2

Multivariate analysis for predictors of DFS and OS.

Characteristics	DFS				OS
	Univariate analysis^a.		Multivariate analysis		Univariate analysis^a.		Multivariate analysis
	HR, 95% CI	value	HR, 95% CI	value	HR, 95% CI	value	HR, 95% CI	value
Age (years)
<65	Ref.				Ref.
≥65	0.79 (0.24-2.56)	0.69			0.78 (0.24-2.56)	0.687
Gender
Female	Ref.				Ref.
Male	0.89 (0.46-1.74)	0.738			0.80 (0.41-1.55)	0.512
ECOG score
0	Ref.				Ref.
1	0.81 (0.37-1.79)	0.608			0.82 (0.37-1.80)	0.62
BMI (kg/m^2)
< 25	Ref.				Ref.
≥ 25	1.21 (0.53-2.76)	0.651			1.19 (0.52-2.71)	0.682
Types of surgery
Laparoscopic gastrectomy	Ref.				Ref.
Open gastrectomy	0.67 (0.35-1.31)	0.244			0.67 (0.35-1.31)	0.243
Pathological TNM stage
I-II	Ref.				Ref.
III	6.15 (3.02-12.54)	<0.001	5.40 (2.460-11.86)	<0.001	6.17 (3.3-12.58)	<0.001	5.00 (2.34-10.67)	<0.001
Complication
No	Ref.				Ref.
Yes	0.87 (0.38-1.99)	0.741			0.89 (0.39-2.03)	0.781
Chemotherapy
No	Ref.				Ref.
Yes	1.42 (0.73-2.73)	0.301			1.35 (0.70-2.61)	0.367
IL6_0
Low	Ref.				Ref.
High	3.54 (1.46-8.60)	0.005	2.98 (1.11-7.98)	0.030	3.67 (1.51-8.92)	0.004	2.67 (1.06-6.72)	0.037
TNFα_0
Low	Ref.				Ref.
High	3.21 (1.56-6.63)	0.002	1.93 (0.91-4.07)	0.086	2.91 (1.44-5.89)	0.003	1.73 (0.83-3.62)	0.144

^aVariables with in univariate analysis were included in multivariate analysis.