Effect of Perioperative Interleukin-6 and Tumor Necrosis Factor-α on Long-Term Outcomes in Locally Advanced Gastric Cancer: Results from the CLASS-01 Trial

Table 3

Multivariate analysis of combined factors of IL6_0 and IL6_5 with DFS and OS.

Characteristics	DFS				OS
	Univariate analysis^b		Multivariate analysis		Univariate analysis^b		Multivariate analysis
	HR, 95% CI	value	HR, 95% CI	value	HR, 95% CI	value	HR, 95% CI	value
Pathological TNM stage
I-II	Ref.				Ref.
III	6.15 (3.02-12.54)	<0.001	5.40 (2.46-11.86)	<0.001	6.17 (3.03-12.58)	<0.001	5.00 (2.34-10.67)	<0.001
Combination of IL6_0 and IL6_5
Group A^a	4.88 (1.64-14.54)	0.004	4.29 (1.42-12.95)	0.010	5.00 (1.67-14.95)	0.004	4.11 (1.35-12.49)	0.013
Group B^a	2.29 (0.72-7.30)	0.162	1.41 (0.42-4.73)	0.582	2.40 (0.75-7.66)	0.140	1.62 (0.48-5.46)	0.439
Group C^a	1.35 (0.30-6.04)	0.694	1.15 (0.21-6.29)	0.871	0.91 (0.17-4.98)	0.916	1.15 (0.21-6.30)	0.869
Group D^a	Ref.				Ref.
TNFα_0
Low	Ref.				Ref.
High	3.21 (1.56-6.63)	0.002	1.93 (0.91-4.07)	0.086	2.91 (1.44-5.89)	0.003	1.73 (0.83-3.62)	0.144

^aGroup A: high IL6_0 and high IL6_5 levels; group B: high IL6_0 and low IL6_5 levels; group C: low IL6_0 and high IL6_5 levels; group D: low IL6_0 and low IL6_5 levels. ^bVariables with in univariate analysis were included in multivariate analysis.