Effect of Perioperative Interleukin-6 and Tumor Necrosis Factor-α on Long-Term Outcomes in Locally Advanced Gastric Cancer: Results from the CLASS-01 Trial

Table 4

Multivariate analysis for complications.

Characteristics	Total complications				Infectious complications
	Univariate analysis^a		Multivariate analysis		Univariate analysis^a		Multivariate analysis
	OR, 95% CI	value	OR, 95% CI	value	OR, 95% CI	value	OR, 95% CI	value
Age (years, ≥ 65)	1.54 (0.40-5.03)	0.498			1.30 (0.33-5.06)	0.707
Gender (male)	2.23 (0.91-6.05)	0.092	2.11 (0.81-5.54)	0.127	1.60 (0.61-4.16)	0.34
ECOG score [1]	1.93 (0.79-4.60)	0.14			2.28 (0.91-5.74)	0.08	2.75 (1.03-7.32)	0.043
BMI (kg/m^2, ≥ 25)	2.50 (0.90-6.66)	0.069	2.87 (1.01-8.16)	0.048	2.64 (0.94-7.42)	0.066	3.42 (1.12-10.46)	0.031
Types of surgery (open gastrectomy)	0.63 (0.27-1.44)	0.277			0.80 (0.33-1.94)	0.624
Pathological TNM stage (III)	1.56 (0.66-3.62)	0.302			1.55 (0.63-3.84)	0.342
Chemotherapy (yes)	1.20 (0.53-2.75)	0.664			1.34 (0.55-3.25)	0.561
IL6_0 (high)	1.56 (0.64-4.12)	0.343			2.31 (0.79-6.77)	0.128
IL6_1 (high)	2.07 (0.77-6.60)	0.178			2.08 (0.66-6.61)	0.213
IL6_3 (high)	1.75 (0.65-5.61)	0.3			1.80 (0.56-5.71)	0.322
IL6_5 (high)	2.11 (0.92-4.97)	0.081	2.07 (0.87-4.96)	0.101	2.48 (1.00-6.18)	0.051	2.69 (1.03-7.01)	0.043
TNFα_0 (high)	0.54 (0.20-1.38)	0.216			0.58 (0.21-1.61)	0.292
TNFα_1 (high)	0.87 (0.33-2.45)	0.777			0.85 (0.30-2.43)	0.777
TNFα_3 (high)	0.65 (0.22-1.70)	0.402			0.67 (0.23-2.03)	0.496
TNFα_5 (high)	0.46 (0.18-1.22)	0.11			0.70 (0.25-1.99)	0.502

^aVariables with in univariate analysis were included in multivariate analysis.