The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma

Figure 7

As a potential downstream target of dBET57, TBX3 plays an important role in NB cells. (a) TBX3 protein level decreased in a gradient-dependent manner with dBET57 concentration. (b) The IGV diagram shows the CHIP-seq spectrum of TBX3. (c) Expression of TBX3 in NB and NC cells. value was determined by unpaired two-sided -test. (d) Tumor profile of TBX3-specific expression (CCLE). In SK-N-BE(2) and IMR-32 cells. (e) TBX3 mRNA and protein expression level. (f) Cell proliferation ability of control group and experimental group. (g) Clonogenic ability of control and experimental groups. Scale bars: 4 mm. (h) Apoptosis ability of control group and experimental group. (i) Migration ability of control and experimental groups. Scale bars: 100 μm. Each sh-TBX3 group was compared with the sh-NC group. , , and ; ns: not significant.

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