Comprehensive Analysis of lncRNA Expression Profile and the Potential Role of ENST00000604491 in Graves’ Disease

Figure 1

The expression profile of lncRNAs in GD. (a) Hierarchical clustering of differentially expressed lncRNAs in PBMCs between the GD and NC groups. The red squares represent upregulated lncRNAs, and the green squares reveal downregulated lncRNAs. (b) Volcano plot of dysregulated lncRNAs between the two groups. The red dots indicate significantly differentially expressed lncRNAs ( and ). (c) The category of dysregulated lncRNAs in GD. (d) A total of 27,354 upregulated and 10,329 downregulated lncRNAs were identified in the GD group compared with the NC group (black). Among them, 2,469 lncRNAs showed upregulated expression and 5,186 showed downregulated expression with over a 1.5-fold change in GD (blue). Eighty-eight significantly differentially expressed lncRNAs, including 5 upregulated and 83 downregulated lncRNAs, were identified ( and ) (red). Each data point represents an individual subject.

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