Suppression of T-Cell Proliferation by Normal Density Granulocytes Led to CD183 Downregulation and Cytokine Inhibition in T-Cells

Figure 3

NDGs downregulate the Th1 marker CD183 on T-cells. T-cells were cultured together with NDGs for 0.5–5 hours, and T-cell subsets were evaluated at different time-points. NDGs did not change the percentage of (a) CD4⁺ cells and (b) CD8⁺ cells. However, the percentage of (c) Th1 cells decreased, and the percentage of (d) Th2 and (e) Th17 cells increased. (f) Subsets of T helper cells were distinguished based on their expression of CD196 and CD183. Graphs (a)–(e) show the median of 5 experiments.

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