Association of HLA-DR1, HLA-DR13, and HLA-DR16 Polymorphisms with Systemic Lupus Erythematosus: A Meta-Analysis

Table 3

Results of the association between HLA-DRB1 (HLA-DR1, HLA-DR13, and HLA-DR16) polymorphisms and SLE susceptibility in this meta-analysis.

Subgroup	No. of studies	Sample size		Test of association		Test of heterogeneity
		SLE	Control	OR (95% CI)		(%)
HLA-DR1
Overall	18	2738	4159	0.76 (0.65, 0.90)	<0.01	0	0.500	0.589	0.405
Caucasian	6	683	789	0.76 (0.58, 0.98)	0.04	0	0.705
East Asian	6	1361	2409	0.79 (0.60, 1.05)	0.11	26.8	0.234
North American	3	356	581	0.64 (0.42, 0.96)	0.03	0	0.913
African	1	75	123	0.45 (0.18, 1.10)	0.08	NA	NA
South Asian	2	263	257	1.53 (0.75, 3.13)	0.25	0	0.485
HLA-DR13
Overall	15	2564	3840	0.58 (0.50, 0.68)	<0.01	29.5	0.135	0.641	0.843
Caucasian	4	560	576	0.62 (0.47, 0.82)	<0.01	0	0.826
East Asian	5	1310	2303	0.44 (0.34, 0.57)	<0.01	14.6	0.321
North American	3	356	581	0.77 (0.50, 1.18)	0.23	53.8	0.115
African	1	75	123	0.56 (0.25, 1.29)	0.17	NA	NA
South Asian	2	263	257	0.88 (0.56, 1.39)	0.59	0	0.363
HLA-DR16
Overall	10	1162	2229	1.70 (1.24, 2.33)	<0.01	37.6	0.108	0.050	0.210
Caucasian	2	336	322	1.46 (0.71, 3.00)	0.30	43.4	0.184
North American	2	131	188	1.69 (0.70, 4.09)	0.24	0	0.388
African	1	75	123	0.54 (0.06, 5.29)	0.60	NA	NA
South Asian	2	263	257	0.53 (0.21, 1.36)	0.19	0	0.951
East Asian	3	357	1339	2.62 (1.71, 4.03)	<0.01	0	0.720

NA: not available.