SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein Antibody Response in SARS-CoV-2 Infection

Table 1

Demographic and analytical characteristics of HCWs included in the study.

	HCWs vaccinated ()	HCW nonvaccinated ()	value
Sex (women)	80.4%	75.0%	0.423
Age (years)			0.809
Time interval infection to serology (days)	22.0 (IQR 14.0-45.0)	18.0 (IQR 11.0-34.0)	0.379
S protein antibodies before infection (BAU/mL)	703.0 (IQR 383.0-1362.0)	N.D.	—
N protein antibodies before infection (index)	0.09 (IQR 0.09-0.10)	0.09 (IQR 0.08-0.10)	0.953
S protein antibodies after infection (BAU/mL)	24,062.0 (IQR 11,753.0-25,000.0)	N.D.	—
N protein antibodies after infection (index)	5.7 (IQR 2.3-15.2)	12.2 (IQR 4.2-32.0)	0.005

Categorical variables are expressed in frequencies, and continuous variables are expressed in median and interquartile range for nonparametrical variables and in mean and standard deviation for parametrical variables. values were obtained using the chi-square test for categorical variables and the Mann-Whitney test (nonparametrical) or Student’s -test (parametrical) for continuous quantitative variables. HCWs: healthcare workers; IQR: interquartile range; S protein: spike protein; N protein: nucleocapsid protein BAU: binding antibody units; N.D.: not determined.