Transmembrane Protein ANTXR1 Regulates γ-Globin Expression by Targeting the Wnt/β-Catenin Signaling Pathway

Figure 7

Molecular mechanisms by which ANTXR1 regulates γ-globin expression via the Wnt/β-catenin signaling pathway. The interaction of ANTXR1 with LRP6 may inhibit the activity of the β-catenin destructive complex consisting of Axin, APC, and Gsk3 via Frizzled. β-Catenin is then free to translocate to the nucleus where it binds to the TCF/LEF transcription factors, thereby promoting the transcription of target gene c-Jun, which, in turn, activates the expression of SOX6, a repressor of γ-globin genes, thereby inhibiting the expression of γ-globin genes.