Different In Situ Immune Patterns between Primary Tumor and Lymph Node in Non-Small-Cell Lung Cancer: Potential Impact on Neoadjuvant Immunotherapy

Figure 2

The in situ immune patterns of T cells and cytotoxic T cells were different in primary tumors (PTs) and metastatic lymph nodes (mLNs). (a, d) The densities of T lymphocytes (CD3+) and cytotoxic T cells (CD8+) were significantly correlated between PTs and mLNs at the center of tumor (CT) and invasive margin (IM) regions. (a) The densities of stromal T lymphocytes (S-CD3+) were significantly higher in mLNs than in PTs at both the CT and IM regions. (b, d) In tumor compartment, the densities of T cells (T-CD3+) and cytotoxic T cells (T-CD8+) were not significantly different. (c) The densities of stromal cytotoxic T cells (S-CD8+) were significantly higher in mLNs than in PTs at IM region. S = stroma; T = tumor; ns = not significant; .

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