The Regulation between CD4⁺CXCR5⁺ Follicular Helper T (Tfh) Cells and CD19⁺CD24^hiCD38^hi Regulatory B (Breg) Cells in Gastric Cancer

Table 1

Association between Tfh, Breg and clinical characteristics of gastric cancer patients.

Clinical characteristic		Tfh			Breg
		M (P25, P75)			M (P25, P75)
Age (year)			111.0	0.163		136.5	0.570
≤60	14	9.97 (7.08, 15.85)			3.32 (1.02, 4.69)
>60	22	7.93 (4.77, 11.17)			2.02 (1.14, 3.89)
Gender			92.0	0.447		84.5	0.295
Male	28	7.93 (6.80, 14.00)			2.77 (1.33, 4.36)
Female	8	7.77 (4.22, 13.12)			1.20 (1.01, 4.79)
Lymph node metastasis			22.0	0.035		37.5	0.182
Negative	32	8.41 (6.83, 14.33)			2.76 (1.19, 4.46)
Positive	4	4.04 (2.293, 9.41)			1.38 (0.94, 2.56)
Depth of invasion			48.0	0.421		62.5	0.940
T1-T2	4	5.72 (4.74, 6.77)			1.47 (0.67, 2.70)
T3-T4	32	8.67 (6.83, 14.33)			2.76 (1.19, 4.46)
Degree of differentiation			119.0	0.525		124.0	0.643
Poor	25	8.63 (6.48, 14.01)			2.81 (1.10, 4.96)
Well	11	7.35 (5.26, 11.03)			2.13 (1.06, 2.97)
Tumor size			107.0	0.127		104.0	0.105
≤5 cm	14	6.84 (4.45, 15.00)			1.82 (1.02, 3.22)
>5 cm	22	8.87 (7.30, 12.63)			3.05 (1.32, 6.48)
TNM stage			53.0	0.053		71.5	0.230
I–II	7	5.26 (3.53, 11.03)			1.73 (0.91, 2.97)
III–IV	29	8.63 (6.91, 14.01)			2.70 (1.22, 4.96)
CEA (0-5 ng/ml)			84.0	0.287		90.0	0.402
≤5	28	8.67 (6.79, 14.33)			2.91 (1.09, 5.21)
>5	8	6.91 (4.63, 11.33)			2.02 (1.21, 2.78)

Mann-Whitney test analysis; significant values are shown with . Tfh: follicular help T cells; Breg: regulatory B cells; TNM: tumor-node-metastasis.