Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population

Table 3

Associations between the six VDR genetic SNVs and susceptibilities to late FRI.

SNVs	Allele or genotype	Patients ()	Controls ()	values	OR (95% CI)
rs7975232	C	480 (71.4%)	492 (66.8%)		Ref.
	A	192 (28.6%)	244 (33.2%)	0.063	0.807 (0.643-1.012)
	CC	166 (49.4%)	167 (45.4%)		Ref.
	AC	148 (44.0%)	158 (42.9%)	0.708	0.942 (0.691-1.285)
	AA	22 (6.6%)	43 (11.7%)	0.018	0.515 (0.295-0.898)
	Dominant (AA+AC vs. CC)			0.285	0.851 (0.633-1.144)
	Recessive (AA vs. AC+CC)			0.019	0.530 (0.310-0.906)
rs1544410	C	645 (96.0%)	692 (94.0%)		Ref.
	T	27 (4.0%)	44 (6.0%)	0.093	0.658 (0.403-1.076)
	CC	310 (92.3%)	325 (88.3%)		Ref.
	CT	25 (7.4%)	42 (11.4%)	0.073	0.624 (0.371-1.049)
	TT	1 (0.3%)	1 (0.3%)	1.000	1.048 (0.065-16.834)
	Dominant (TT+CT vs. CC)			0.079	0.634 (0.380-1.057)
	Recessive (TT vs. CT+CC)			1.000	1.096 (0.068-17.584)
rs2228570	A	333 (49.6%)	331 (45.0%)		Ref.
	G	339 (50.4%)	405 (55.0%)	0.085	0.832 (0.675-1.026)
	AA	80 (23.8%)	66 (17.9%)		Ref.
	AG	173 (51.5%)	199 (54.1%)	0.090	0.717 (0.488-1.053)
	GG	83 (24.7%)	103 (28.0%)	0.066	0.665 (0.430-1.028)
	Dominant (GG+AG vs. AA)			0.055	0.699 (0.485-1.008)
	Recessive (GG vs. AG+AA)			0.323	0.844 (0.603-1.182)
rs731236	A	647 (96.3%)	700 (95.1%)		Ref.
	G	25 (3.7%)	36 (4.9%)	0.281	0.751 (0.446-1.265)
	AA	311 (92.6%)	334 (90.8%)		Ref.
	AG	25 (7.4%)	32 (8.7%)	0.528	0.839 (0.486-1.448)
	GG	0 (0.0%)	2 (0.5%)	0.500	1.006 (0.998-1.014)
	Dominant (GG+AG vs. AA)			0.390	0.790 (0.461-1.354)
	Recessive (GG vs. AG+AA)			0.500	1.005 (0.998-1.013)
rs4516035	T	644 (95.8%)	718 (97.6%)		Ref.
	C	28 (4.2%)	18 (2.4%)	0.070	1.734 (0.950-3.165)
	TT	308 (91.7%)	350 (95.1%)		Ref.
	CT	28 (8.3%)	18 (4.9%)	0.065	1.390 (0.772-2.504)
	CC	0 (0.0%)	0 (0.0%)	N/A	N/A
	Dominant (CC+CT vs. TT)			0.065	1.768 (0.959-3.259)
	Recessive (CC vs. CT+TT)			N/A	N/A
rs11568820	C	380 (56.5%)	432 (58.7%)		Ref.
	T	292 (43.5%)	304 (41.3%)	0.415	1.092 (0.884-1.349)
	CC	106 (31.5%)	133 (36.1%)		Ref.
	CT	168 (50.0%)	166 (45.1%)	0.160	1.270 (0.910-1.772)
	TT	62 (18.5%)	69 (18.8%)	0.582	1.127 (0.735-1.729)
	Dominant (TT+CT vs. CC)			0.199	1.228 (0.898-1.680)
	Recessive (TT vs. CT+CC)			0.919	0.981 (0.670-1.434)

FRI: fracture-related infection; SNV: single nucleotide variation; OR: odds ratio, CI: confidence interval; N/A: not available.