Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population

Table 4

Preoperative serological levels of inflammatory biomarkers and vitamin D among different genotypes of rs7975232 in FRI patients.

rs7975232	WBC (×10^9/l)	PMN (%)	ESR (mm/1 h)	CRP (mg/l)	PCT (ng/ml)	IL-6 (pg/ml)	TNF-α (pg/ml)	SAA (mg/l)	Vitamin D (ng/ml)
AA	6.0 (5.2, 7.6)	59.5 (53.9, 63.3)	14 (7.5, 48.5)	4.6 (1.8, 14.2)	0.037 (0.029, 0.082)	7.3 (3.7, 13.8)	8.1 (6.8, 9.3)	8.5 (5.0, 28.2)	20.6 (19.6, 24.6)
AC	7.1 (5.6, 8.3)	59.2 (50.1, 65.5)	16 (8, 33)	4.5 (1.5, 10.4)	0.045 (0.034, 0.067)	5.9 (3.5, 10.7)	9.3 (7.6, 11.8)	10.7 (6.4, 31.4)	20.3 (15.0, 24.0)
CC	6.9 (5.8, 8.4)	60.0 (51.8, 66.9)	15 (7.0, 36.8)	3.9 (1.4, 13.1)	0.043 (0.027, 0.068)	6.1 (3.4, 12.7)	9.4 (7.6, 11.9)	10.8 (6.2, 19.1)	17.9 (13.5, 22.9)
P values	0.257	0.779	0.639	0.933	0.745	0.833	0.068	0.632	0.021
Post hoc multiple comparisons^#
AA vs. AC	0.110	0.981	0.863	0.715	0.897	0.563	0.022	0.330	0.286
AA vs. CC	0.113	0.698	0.561	0.737	0.654	0.557	0.031	0.403	0.019
AC vs. CC	0.923	0.505	0.390	0.925	0.471	0.963	0.969	0.826	0.035

FRI: fracture-related infection; WBC: white blood cell count; PMN%: percentage of polymorphonuclear; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; PCT: procalcitonin; IL-6: interleukin-6; TNF-α: tumor necrosis factor-α; SAA: serum amyloid A. These values were obtained by the Kruskal-Wallis H test. ^#The alpha level was 0.017 for the post hoc multiple comparisons.