Identification of Three Prognosis-Related Differentially Expressed lncRNAs Driven by Copy Number Variation in Thyroid Cancer

Figure 5

Identification of lncRNAs driven by CNV. (a) Distribution of lncRNA copy deletions and amplification in the genome. (b) Correlation distribution of CNV and expression of lncRNAs: light red represents the distribution under actual conditions, light blue represents the distribution under random conditions, and the difference between the two distributions is assessed by the T-test. (c–d) LincRNAs located in the focal CNA peaks are THCA-related. False-discovery rates ( values) and scores from GISTIC 2.0 for alterations (x-axis) are plotted against genome positions (y-axis); the dotted lines show the centromeres. The deletions (right and blue) and amplifications (left and red) of lincRNA genes are presented. The green line shows 0.25 value cutoff point that determines significance.

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