The Invasion and Metastasis of Colon Adenocarcinoma (COAD) Induced by SALL4

Figure 5

(a) The overexpression of SALL4 promoted EMT, which was manifested as downregulation of E-cadherin as well as the upregulation of N-cadherin, vimentin, and Twist. (b) On the contrary, knockout of SALL4 gene reversed EMT and inhibited EMT phenotype, which was manifested as upregulation of E-cadherin as well as the downregulation of N-cadherin, vimentin, and Twist expression.

(a)

(b)