Blockade of NLRP3/Caspase-1/IL-1β Regulated Th17/Treg Immune Imbalance and Attenuated the Neutrophilic Airway Inflammation in an Ovalbumin-Induced Murine Model of Asthma

Figure 1

Ovalbumin sensitization, challenge, and intervention protocol. Balb/c mice were systemically sensitized by subcutaneous injection with OVA/CFA on day 0 and then challenged with OVA aerosols on days 21 and 22. MCC950 was administrated into mice by intraperitoneal injections for three consecutive days before the aerosols. Three hours before each exposure to aerosol, mice were injected intraperitoneally with Ac-YVAD-cmk. OVA: ovalbumin; CFA: complete Freund’s adjuvant.