Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma

Figure 3

(a) Analysis of differences in tumor purity between three immune subtypes. Tumor purity was importantly more down in Immunity_H group and importantly more excellent in Immunity_L (, Kruskal-Wallis test). (b) Survival analysis of three immune subgroups. The survival curves of Immunity_L, Immunity_M, and Immunity_H subgroups were significantly different (). It also proved that immune grouping had a good predictive effect on the survival of DLBCL. Patients in Immunity_H had the best prognosis, patients in Immunity_L had got the poorest prognosis, and the Immunity_M was between them. (c–h) The expression of PD-1, PD-L1, CD3D, HIF1A, IRF4, and other genes was meaningfully correlated with the immune subgroup. The expressions of PD-1, PD-L1, CD3D, HIF1A, IRF4, and other genes were meaningfully dissimilar between Immunity_L and Immunity_H (ANOVA text, ).

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