Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma

Figure 4

(a) Immune subsets were significantly associated with HLA family genes. Among 24 HLA-related genes, only five genes, HLA-G, HLA-DRB6, HLA-DPB2, HLA-DOB, and HLA-B, were not significant in the distribution of immune subsets. The remaining HLA family members were statistically distributed in the immune subgroups (). (b) Immune subtypes were significantly associated with immune cell infiltration. Monocytes, M1 macrophages, M2 macrophages, CD8⁺ T cells, CD4⁺ memory-activated T cells, and follicular helper T cells were substantially high up in the Immunity_H group than in the Immunity_M groups and Immunity_L. The results of B cells naive, B cells memory, plasma cells, and CD4⁺ naive T cells in Immunity_L were considerably more excellent than those in Immunity_M and Immunity_H. (c and d) GO and KEGG analysis differential gene enrichment analysis of Immunity_H and Immunity_L groups.

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