Molecular Allergy Diagnostics in Children with Cow’s Milk Allergy: Prediction of Oral Food Challenge Response in Clinical Practice

Table 2

Predictive factors for a positive response to CM challenge.

	Negative challenge (n = 42; 58.4%)	Positive challenge (n = 30; 41.6%)	p	AUC (95% CI)	Cutoff	Spec.	Sens.
Age (months)	60.8 ± 49.81	86.7 ± 62.71	0.05
Sex
Females	11 (26.2%)	9 (30.0%)	0.79
Males	31 (73.8%)	21 (70.0%)
Severity of reaction
Mild	9 (23.1%)	10 (41.7%)	0.27
Moderate	15 (38.5%)	6 (25.0%)
Severe	15 (38.5%)	8 (33.3%)
Total IgE (kU/L)	605.7 ± 1227.47	661.4 ± 1041.39	0.65
IgE to cow’s milk (kUA/L)	8.4 ± 14.72	22.8 ± 30.89	0.03	0.65 (0.52–0.79)	5.13	70.0%	65.5%
IgE to Bos d 4 (α-lactalbumin) (kUA/L)	2.8 ± 5.76	11.1 ± 21.66	0.013	0.68 (0.55– 0.81)	1.47	71.1%	62.1%
IgE to Bos d 5 (β-lactoglobulin) (kUA/L)	2.8 ± 5.62	6.5 ± 12.68	0.09	0.62 (0.49–0.76)	1.35	67.6%	58.6%
IgE to Bos d 8 (casein) (kUA/L)	5.5 ± 10.74	18.5 ± 27.57	0.019	0.67 (0.54–0.81)	4.87	81.6%	51.9%
Total daily cumulative dose administered on the last day of the challenge (mL)	23.7 ± 33.03	27.2 ± 43.79	0.17