Identification of Hub Biomarkers and Immune and Inflammation Pathways Contributing to Kawasaki Disease Progression with RT-qPCR Verification

Figure 2

Development of the creation of WGCNA modules: (a) cluster dendrogram of genes whose median absolute deviation is among the top 25% of the range. The lines in the diagram represent a gene, and the colors denote the coexpression modules associated with those genes; (b) a heatmap illustrates the relationships between the modules and the traits. A powerful connection was found between the blue module and KD; (c) a representation of the distribution of the mean gene significance between KD-related modules; (d) a scatter plot shows the connection between membership in the blue module of the gene module and the level of relevance of the gene. Abbreviations: KD, Kawasaki disease; WGCNA, weighted gene coexpression network analysis.

(a)

(b)

(c)

(d)