Identification of Hub Biomarkers and Immune and Inflammation Pathways Contributing to Kawasaki Disease Progression with RT-qPCR Verification

Figure 4

Using GO keywords in the study of differentially expressed genes in biological processes, the first lap represents the top 18 GO keywords, while the outer lap indicates the total number of genes. During the second pass, the number of genes already present in the genomic background and the P-values linked with the enrichment of DEGs for biological processes were retrieved. In the third lap, we compare the number of genes that were elevated (dark purple) with the number of genes that were downregulated (light purple). The fourth circuit represents the enrichment factor of each GO word in the diagram in the figure. Abbreviations: DEG, differentially expressed genes; GO, Gene Ontology.