Research Article
Identification of Hub Biomarkers and Immune and Inflammation Pathways Contributing to Kawasaki Disease Progression with RT-qPCR Verification
Table 1
Top 15 significant immunological signatures enriched by DEGs in GSEA.
| | Gene set name | NES | P-value | NOM p.adjust | FDR q-values |
| | GSE22886 NAÏVE BCELL VS. NEUTROPHIL DN | 3.221629 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE6269 HEALTHY VS. STAPH PNEUMO INF PBMC DN | 3.19896 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE7400 CTRL VS. CSF3 IN VIVO TREATED PBMC DN | 3.180609 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE6269 E COLI VS. STREP PNEUMO INF PBMC DN | 3.135927 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE6269 FLU VS. STAPH AUREUS INF PBMC DN | 3.102818 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE22886 NAÏVE TCELL VS. NEUTROPHIL DN | 3.097563 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE4748 CYANOBACTERIUM LPSLIKE VS. LPS AND CYANOBACTERIUM LPSLIKE STIM DC 3 H DN | 3.078676 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE29618 MONOCYTE VS. PDC UP | 3.035813 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE22886 NAÏVE TCELL VS. MONOCYTE DN | 3.030273 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE22886 NAÏVE CD4+ TCELL VS. MONOCYTE DN | 3.014044 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE4984 UNTREATED VS. GALECTIN1 TREATED DC UP | 2.999805 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE29618 MONOCYTE VS. PDC DAY7 FLU VACCINE UP | 2.998979 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE34205 HEALTHY VS. RSV INF INFANT PBMC DN | 2.991961 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE29618 MONOCYTE VS. MDC UP | 2.991289 | 1.00E-10 | 2.93E-09 | 1.83E-09 | | GSE22886 NAÏVE CD8+ TCELL VS. MONOCYTE DN | 2.976089 | 1.00E-10 | 2.93E-09 | 1.83E-09 |
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DEGs, differentially expressed genes; GSEA, gene set enrichment analysis; NES, normalized enrichment score; NOM, nominal; FDR, false discovery rate.
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