Research Article

Activation of Most Toll-Like Receptors in Whole Human Blood Attenuates Platelet Deposition on Collagen under Flow

Figure 2

TLR ligands (except LPS) inhibit platelet deposition onto collagen under flow. PPACK WB treated with HBS (control) or TLR ligands was perfused over collagen at 100 s-1 for 720 seconds. CD61 was added to all channels to label platelets. Platelet FI was measured throughout the course of the experiments (a) and Figure 2(b) shows how they looked under the microscope at the end point.
(a)
(b)