Activation of Most Toll-Like Receptors in Whole Human Blood Attenuates Platelet Deposition on Collagen under Flow

Figure 4

Activation of TLR7 can strongly inhibit platelet-platelet aggregation. PPACK WB treated with control (HBS); TLR7 ligands were perfused over collagen at 100 s^-1 with or without switching. CD61 was used to label platelets. Fluorescence intensities for platelets were measured throughout the course of the experiments for Imquimod (a), GSK2245035 (b), and Vesatolimod (c). Molecular structure of different TLR 7 ligands were shown in Figures 4(d), 4(e), and 4(f).

(a)

(b)

(c)

(d)

(e)

(f)